目的　观察肝硬化患者血浆降钙素基因相关肽 (CGRP)和内皮素 (ET 1)含量变化。方法　选择肝硬化患者 6 0例 (其中腹水患者 4 3例 )、正常对照 30例 ,用放射免疫法检测其血浆CGRP和ET 1含量。结果　肝硬化组血浆CGRP和ET 1明显高于对照组 (P <0 0 1) ;肝硬化腹水患者高于无腹水患者 (P <0 0 1) ;肝功能Child Pugh分级中C级高于B级、B级高于A级。结论　肝硬化患者血浆CGRP和ET 1水平增高 ,CGRP及ET 1在肝功能损伤及肝硬化高动力循环状态的发生中具有重要作用 Objective To observe the changes of plasma calcitonin gene - related peptide (CGRP) and endothelin (ET 1) in cirrhotic patients. Methods Sixty patients with cirrhosis (including 43 patients with ascites) and 30 normal controls were enrolled in this study. Plasma CGRP and ET 1 levels were measured by radioimmunoassay. Results The levels of plasma CGRP and ET 1 in cirrhosis group were significantly higher than those in control group (P <0.01); patients with cirrhosis and ascites were higher than those without ascites (P <0.01) Grade, B grade is higher than A grade. Conclusions Patients with liver cirrhosis have elevated plasma CGRP and ET 1 levels and CGRP and ET 1 play an important role in the pathogenesis of hepatic injury and cirrhosis and hyperdynamic circulation