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分别用去甲肾上腺素(NE)、牛血清白蛋白(BSA)、NE+BSA诱发免血瘀证模型,结果三组造型后所检测指标均有不同程度的改变,尤以NE+BSA组改变最为明显。其中,NE+BSA组与正常对照组比较,其高切率全血粘度、低切率全血粘度、血浆粘度、全血还原粘度以及血浆TXB_2含量、红细胞IC花环率均明显升高;血小板1min聚集率与血小板最大聚集率及红细胞聚集均明显增加;血浆6—Keto—PGF_(1α)含量、红细胞C_(3h)受体花环率均明显降低;肠系膜微循环血流流速减慢,以粒流、粒缓流为主。以上各改变与正常对照组比较差别均有显著或非常显著性意义(P<0.05或P<0.01)。提示NE与BSA合用可使造型兔产生高浓、高粘、高聚、高凝的血瘀证病理状态,与血瘀证的临床改变相似,也与血瘀证的中医病理机制相符,故可认为此血瘀证模型为一较稳定、理想的慢性血瘀证模型,可用于血瘀证实质的探讨及活血化瘀方药作用机理的研究。
Norepinephrine (NE), bovine serum albumin (BSA) and NE+BSA were used to induce the blood-stasis syndrome model respectively. The results showed that the indexes detected in the three groups changed to varying degrees, especially in the NE+BSA group. The most obvious. Among them, compared with the normal control group, the NE+BSA group had high cut rate, whole blood viscosity, low cut rate, whole blood viscosity, plasma viscosity, whole blood reduced viscosity, plasma TXB_2 content, and red blood cell IC rosette rate. The platelet count was 1 min. Aggregation rate, platelet maximal aggregation rate and erythrocyte aggregation were significantly increased; plasma 6-Keto-PGF(1α) content, erythrocyte C_(3h) receptor rosette rate were significantly reduced; mesenteric microcirculation blood flow velocity was slowed down, and flow was reduced. Mainly slow flow. The above changes were significantly or very significant compared with the normal control group (P<0.05 or P<0.01). It is suggested that the combined use of NE and BSA can lead to high-concentration, high-viscosity, high-aggregation, hypercoagulable pathological state of blood stasis syndrome in rabbits. It is similar to the clinical change of blood stasis syndrome and is consistent with the traditional Chinese medicine pathological mechanism of blood stasis syndrome. The blood stasis syndrome model is considered to be a more stable and ideal model of chronic blood stasis syndrome. It can be used for the exploration of the essence of blood stasis syndrome and the study on the mechanism of action of blood stasis and stasis prescription.