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作为ATP门控离子通道之一,P2X7受体以其独特的生理结构在癫痫发病机制中颇受关注,在具体的动物模型可见该受体表达的变化,其机制有P2X7受体在炎症因子产生中的重要作用、与对谷氨酸递质的释放及再摄取的调节有关。
As one of the ATP-gated ion channels, P2X7 receptor has attracted much attention in the pathogenesis of epilepsy due to its unique physiological structure. The expression of P2X7 receptor in the animal model is characterized by P2X7 receptor production in inflammatory cytokines In the important role, and glutamate neurotransmitter release and re-uptake regulation.