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目的进一步探究复方甘草酸苷对慢性乙型肝炎患者生物化学检查指标的影响。方法择取2014年9月~2016年9月在我院接受治疗的152例慢性乙型肝炎患者进行回顾分析。依据随机数字表法将其均分至复方甘草酸苷联合恩替卡韦治疗的观察组,与单纯使用恩替卡韦治疗的对照组。对比分析复方甘草酸苷对慢性乙型肝炎患者生化检验指标的影响情况。结果无论HBs Ag转阴率、HBe Ag转阴率,还是HBe Ab转阳率和HBV-DNA转阴率方面,观察组患者各指标均明显优于单一用药的对照组,P<0.05,统计学意义明显。同时,经治疗后随访发现,采用复方甘草酸苷治疗的观察组其ALT复常率、IL-6及TNF-α水平等指标同样明显优于对照组,二者差异显著,统计学意义明显。结论对于慢性乙型肝炎患者采取复方甘草酸苷联合恩替卡韦方案进行治疗不仅能够有效抑制患者肝细胞炎症因子,而且能够促进IL-12的分泌,进而有效抑制病毒复制,增强病毒清除作用。
Objective To further investigate the effect of compound glycyrrhizin on biochemical indexes in patients with chronic hepatitis B. Methods A total of 152 patients with chronic hepatitis B treated in our hospital from September 2014 to September 2016 were retrospectively analyzed. According to random number table method, they were equally divided into compound glycyrrhizin group and entecavir treatment group, compared with the simple use of entecavir treatment group. Comparative analysis of compound glycyrrhizin in patients with chronic hepatitis B biochemical indicators. Results Regardless of HBsAg negative rate, HBeAg negative rate, HBeAb positive rate and HBV-DNA negative rate, the indicators in the observation group were significantly better than the single control group, P <0.05, statistics Significant meaning. At the same time, after treatment, follow-up found that compound glycyrrhizin treatment group ALT normalization rate, IL-6 and TNF-α and other indicators were also significantly better than the control group, the difference was significant and statistically significant. Conclusion The treatment of compound glycyrrhizin combined with entecavir in patients with chronic hepatitis B can not only effectively inhibit the hepatocyte inflammatory factor in patients with chronic hepatitis B, but also promote the secretion of IL-12, thereby effectively inhibiting the virus replication and enhancing the virus clearance effect.