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目的:探讨牛肺表面活性物质和猪肺表面活性物质治疗新生儿呼吸窘迫综合征临床疗及安全性差异。方法:研究对象选取我院2010年2月-2015年7月收治新生儿呼吸窘迫综合征患儿共60例,随机分为A组(30例)和B组(30例),分别给予牛肺表面活性物质和猪肺表面活性物质治疗治疗;比较两组患儿机械通气时间,治疗前后血气分析指标水平及并发症发生率等。结果:A组和B组患儿机械通气时间分别为(5.26±1.04)d,(4.11±0.87)d;B组患儿机械通气时间显著短于A组,差异有统计学意义(P<0.05);两组患儿治疗后12h血气分析指标水平比较差异无统计学意义(P>0.05);两组患儿并发症发生率比较差异无统计学意义(P>0.05)。结论:牛肺表面活性物质和猪肺表面活性物质治疗新生儿呼吸窘迫综合征临床疗及安全性接近,但猪肺表面活性物质可有效缩短机械通气时间,更具临床应用价值。
Objective: To investigate the clinical efficacy and safety of bovine pulmonary surfactant and porcine pulmonary surfactant in the treatment of neonatal respiratory distress syndrome. Methods: The subjects selected from our hospital from February 2010 to July 2015 admitted to neonatal respiratory distress syndrome in 60 cases, were randomly divided into A group (30 cases) and B group (30 cases), were given bovine lung Surfactant and pulmonary surfactant were used for treatment. The mechanical ventilation time, blood gas analysis index and complication rate before and after treatment were compared between the two groups. Results: The duration of mechanical ventilation in group A and group B was (5.26 ± 1.04) days and (4.11 ± 0.87) days, respectively. The duration of mechanical ventilation in group B was significantly shorter than that in group A (P <0.05) ). There was no significant difference in blood gas analysis indexes between the two groups at 12h after treatment (P> 0.05). There was no significant difference in the complication rates between the two groups (P> 0.05). CONCLUSION: Bovine pulmonary surfactant and swine lung surfactant are effective in treating neonatal respiratory distress syndrome. However, the pulmonary surfactant can shorten the time of mechanical ventilation and has clinical value.