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目的:观察大鼠脑出血后应用碱性成纤维细胞生长因子(bFGF)对血肿周围脑组织含水量变化的影响。方法:72只大鼠随机分为假手术组、生理盐水对照组和bFGF组,每组又根据观察时间不同分为1、3、7d组,每组8只,采用胶原酶脑内定点注射建立脑出血模型,各组大鼠到相应时间点后处死取脑,应用干湿比重法测定脑组织含水量。结果:bFGF组与生理盐水组比较,1、3、7d血肿周围脑组织含水量均下降,差异有统计学意义(P<0.05)。结论:bFGF能有效减轻大鼠脑出血后脑水肿的形成,从而对脑出血后脑损伤具有保护作用。
Objective: To observe the effect of basic fibroblast growth factor (bFGF) on the changes of water content in the perihematomal brain tissue after intracerebral hemorrhage in rats. Methods: Seventy-two rats were randomly divided into sham operation group, saline control group and bFGF group. Each group was divided into three groups according to the observation time: 1,3,7d group, 8 rats in each group. Intravenous injection of collagenase Intracerebral hemorrhage model, the rats in each group were sacrificed at the corresponding time points to take brain, and the water content of brain tissue was measured by the wet-dry proportion method. Results: Compared with saline group, the water content of brain tissue around the hematoma of bFGF group decreased on the 1st, 3rd, 7th day, the difference was statistically significant (P <0.05). Conclusion: bFGF can effectively reduce the formation of cerebral edema after intracerebral hemorrhage in rats and thus have a protective effect on brain injury after intracerebral hemorrhage.