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一、受体的发现受体的概念是英国药理学家兰雷(Langley)首先提出来的。1878年,他在研究阿托平和毛果云香碱对猫唾液分泌的影响时,发现两者有对抗作用,为了解释这种现象,他设想效应器上有一种接受物质(receptive substance)。1906年,他又发现箭毒和菸碱对骨骼肌有对抗作用,为了解释其作用机制,他更明确地提出在肌肉的神经区域内,存在一种能与箭毒和菸碱结合的接受物质,箭毒同它结合,引起骨骼肌松弛,菸碱同它结合,引起骨骼肌兴奋。兰雷当时设想的接受物质,就是最原始的受体概念。首先使用受体(receptor)一词的是德国细菌学家欧利希(Ehrlich)。1909年,他根据自己的研究,认为兰雷所说的接受物质可能是一种化学基团,这种化学基团能和组织的营养物质、化学信使或药物结合,引起生物效应,并提出“除非结合,物质不会发生作用”的名
First, the discovery of the receptor Receptors concept is first proposed by the British pharmacologist Langley (Langley). In 1878 he was investigating the effects of atropine and pilocarpine on cat saliva secretion and found that they both had antagonistic effects. To account for this phenomenon, he envisaged a receptive substance on the effector. In 1906, he also found that arrowhead poison and nicotine had antagonistic effects on skeletal muscle. In order to explain its mechanism of action, he even more clearly proposed that there is a receptor capable of binding arrowhead poison and nicotine in the muscle nerve area , Arrowhead with it, causing skeletal muscle relaxation, nicotine with it, causing skeletal muscle excitement. The material accepted by Ranley at that time was the most primitive concept of the receptor. The first to use the term receptor is the German bacteriologist Ehrlich. In 1909, according to his own research, he considered that Rayleigh’s acceptance of the substance may be a chemical group that can combine with the tissue’s nutrients, chemical messengers or drugs to cause a biological effect and put forward “ Unless combined, matter does not work ”