本文合成了九个小檗碱类衍生物(Ⅲ_(a～g),Ⅳ,Ⅴ),其中Ⅲ_(c～g)和Ⅴ为尚未见诸文献的新化合物。Ⅲ_a只有由植物提取的报导。九个化合物经艾氏腹水癌瘤株初步筛选,说明Ⅲ_a和Ⅳ具明显抗癌活性。 Nine berberine derivatives (Ⅲ_ (a ~ g), Ⅳ, Ⅴ) were synthesized in this paper. Among them, Ⅲ_ (c ~ g) and Ⅴ are new compounds which have not been found in the literature. III_a Only reports from plants. Nine compounds were initially screened by Ehrlich’s ascites carcinoma line, indicating that Ⅲ_a and Ⅳ have obvious antitumor activity.