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目的:探讨家庭聚集性慢性HBV感染者HBVYMDD自然变异发生情况以及影响其变异的因素.方法:筛选34个共95例有乙型肝炎家庭聚集现象且未经抗病毒治疗的慢性乙型肝炎(chronic hepatitis B,CHB)患者作为家庭组,进行YMDD检测;随机选择82例无乙型肝炎家庭聚集现象且未接受过抗病毒治疗的CHB患者作为对照组,进行YMDD检测.结果:家庭组95例中有51例(53.68%)检测到YMDD自然变异,对照组82例中有21例(25.61%)检测到YMDD自然变异;YMDD自然变异检出率有显著性差异(P<0.05).结论:有乙型肝炎家族聚集史慢性HBV感染者的YMDD自然变异率较没有乙型肝炎家族聚集史慢性HBV感染者的YMDD自然变异率高.
Objective: To investigate the occurrence of HBVYMDD and the factors that affect its variation in patients with chronic HBV infection.Methods: A total of 95 patients with chronic hepatitis B (chronic hepatitis B without chronic viral hepatitis B YMDD was used to detect hepatitis B (CHB) and family B (CHB) .The YMDD test was performed in 82 CHB patients without hepatitis B family history and without antiviral therapy.Results: The natural variation of YMDD was detected in 51 cases (53.68%) and the natural variation of YMDD in 21 cases (25.61%) of 82 cases in the control group, and the detection rate of YMDD was significantly different (P <0.05) .Conclusion: The natural mutation rate of YMDD in patients with chronic HBV infection is higher than that of patients with chronic hepatitis B virus infection in the absence of hepatitis B family history.