前脑无裂畸形(Holoprosencephaly,HPE)也称全前脑,是前脑完全或部分未分裂而导致的脑畸形和由此引起的一系列面部畸形,是一种罕见但死亡率极高的胎儿先天发育异常。由于前脑无裂畸形胎儿死亡率较高,部分轻型病例虽可存活,但会出现严重的智力、运动障碍[1]。本文报告病例如下。1病例资料患儿,女,1岁,G1P1,足月顺产,有生时窒息缺氧史,Apgar评分7-9分,否认黄疸迁延史。患儿运动发育 Holoprosencephaly (HPE), also known as the whole forebrain, is a rare but high-risk fetus with brain deformities caused by the complete or partial absence of the forebrain and a series of facial deformities Congenital dysplasia. Due to the higher rate of fetal mortality in the absence of anterior segment of the brain, some light-weight cases may survive, but severe mental and physical disorders may occur [1]. The following are the cases reported in this article. 1 Case data Children, 1 year old, G1P1, full-term follow-up, history of asphyxial hypoxia during pregnancy, Apgar score 7-9 points, denied the history of jaundice delay. Children with motor development