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目的 研究短暂性脑缺血发作 (TIA)患者血浆纤溶功能的变化。方法 对 2 2例颈内动脉系统TIA患者血浆组织型纤溶酶原激活物 (t PA)及其快速抑制物 (PAI)的活性、D 二聚体 (D D)及纤维蛋白原 (FbG)含量进行检测 ,并与对照组进行比较。结果 TIA组血浆t PA活性明显低于对照组 (P <0 .0 5 ) ,而PAI活性和D D及FbG含量则明显高于对照组 (P <0 .0 5 )。结论 TIA患者存在血浆纤溶功能异常 ,可能为TIA反复发作的一个重要因素
Objective To study the changes of plasma fibrinolytic function in patients with transient ischemic attack (TIA). Methods The levels of plasma t-PA and PAI and the levels of D dimer (DD) and fibrinogen (FbG) in 22 patients with TIA in the internal carotid artery system were measured. The test was performed and compared with the control group. Results The plasma t PA activity in TIA group was significantly lower than that in control group (P <0.05), while PAI activity and D D and FbG contents in TIA group were significantly higher than those in control group (P <0.05). Conclusion TIA patients with abnormal plasma fibrinolytic function may be an important factor in repeated episodes of TIA