急性冠脉综合征发病的病理基础为冠状动脉粥样硬化斑块破裂,血小板黏附、聚集和释放,凝血系统激活形成血栓,同时可伴血管痉挛,引起血管腔明显狭窄或闭塞[1]。急性冠脉综合征易发生心肌梗死或心源性猝死,预后差,故采取及时有效的治疗至关重要。普通肝素由于有出血,诱导血小板减 Pathological basis for the pathogenesis of acute coronary syndrome is coronary atherosclerotic plaque rupture, platelet adhesion, aggregation and release, the activation of the coagulation system to form thrombus, with vasospasm, resulting in significant stenosis or occlusion of the vascular lumen [1]. Acute coronary syndromes are prone to myocardial infarction or sudden cardiac death, the prognosis is poor, it is essential to take timely and effective treatment. Unfractionated heparin due to bleeding, induced thrombocytopenia