目的　评估国产铝碳酸镁 (威地美 )和进口同类产品 (达喜 )治疗胆汁反流性胃炎的疗效及安全性。方法　 30例伴有腹痛、反酸、恶心、呕吐胆汁患者由胃镜诊断为胆汁反流性胃炎 ,并经胃内 2 4h胆汁监测证实。患者分为两组 ,试验组 15例 ,给予国产铝碳酸镁 1.0 g ,每天 3次 ;对照组 15例 ,给予进口产品 1.0 g ,每天 3次 ,疗程均为 4周。治疗前、后均采用Bilitec测定胃内胆汁酸。观察治疗前后临床症状积分、临床症状消失时间、胃内胆汁酸变化以及药物不良反应。结果　试验组治疗 2、4周后烧心、上腹痛、上腹胀、嗳气、反酸、呕吐胆汁样物等症状均明显减轻 (P <0 .0 5 ) ,总有效率为 10 0 %。与对照组相比疗效相当。两组在治疗过程中 ,烧心、上腹痛、上腹胀、嗳气、反酸、呕吐胆汁样物等症状的消失时间也相当。试验组腹痛完全消失时间为 (7.2± 3.1)d ,对照组为 (6 .9± 4 .8)d。Bilitec监测结果显示 :试验组 2 4h胃内胆汁反流总时间百分比由治疗前的 (17.0± 16 .3) %降至 (4.9± 4 .5 ) % (P <0 .0 5 ) ,对照组由治疗前的 (16 .8± 6 .9) %降至 (3.2± 2 .3) % (P <0 .0 5 )。两组均未见明显的不良反应。结论　国产铝碳酸镁可结合胃内胆汁 ,有效缓解胆汁反流性胃炎症状 ,是治疗胆汁反流性胃炎安全、有效的药 Objective To evaluate the efficacy and safety of domestic magnesium aluminum carbonate (Granville United States) and similar imported products (Daxi) in the treatment of bile reflux gastritis. Methods Thirty patients with abdominal pain, acid reflux, nausea and vomiting were diagnosed as bile reflux gastritis by endoscopy and confirmed by 24 h bile in the stomach. Patients were divided into two groups, the experimental group of 15 cases, given domestic magnesium aluminum carbonate 1.0 g, 3 times a day; control group of 15 cases, to give the imported product 1.0 g, 3 times a day for 4 weeks. Before and after treatment, Bilitec was used to measure intragastric bile acid. The scores of clinical symptoms, disappearance of clinical symptoms, changes of gastric bile acid and adverse drug reactions were observed before and after treatment. Results After 2 and 4 weeks of treatment, the symptoms such as heartburn, upper abdominal pain, abdominal distension, belching, acid reflux and vomiting bile samples were significantly relieved in the experimental group (P 0.05). The total effective rate was 100%. Compared with the control group, the effect is quite good. Two groups in the course of treatment, heartburn, upper abdominal pain, abdominal distension, belching, acid reflux, vomiting bile-like symptoms disappear time is also quite. In the test group, the complete disappearance of abdominal pain was (7.2 ± 3.1) days and that in the control group was (6.9 ± 4.8) days. The results of Bilitec monitoring showed that the percentage of total bile reflux during 24 hours in experimental group decreased from (17.0 ± 16.3)% to (4.9 ± 4.5)% (P <0.05) in control group From (16.8 ± 6.9)% before treatment to (3.2 ± 2.3%) (P <0.05). No obvious adverse reactions were seen in both groups. Conclusion Domestic magnesium aluminum carbonate can be combined with intragastric bile, effectively relieve the symptoms of bile reflux gastritis, is safe and effective treatment of bile reflux gastritis