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左炔诺孕酮宫内缓释系统是一种安全、高效的宫内节育器,近年来还被用于治疗月经过多等妇科疾病并取得较好的效果,但其主要不良反应即子宫内膜的不规则突破性出血至今仍未妥善解决。近年研究表明,子宫内膜血管结构和功能的异常是左炔诺孕酮宫内缓释系统引起不规则出血的原因,而与子宫内膜血管生成和血管稳定性有关的各种因子的改变是其分子生物学基础,现就此作一综述。
Levonorgestrel intrauterine release system is a safe and efficient IUD, and in recent years has also been used to treat menorrhagia and other gynecological diseases and achieved good results, but the main adverse reactions that intrauterine Irregular breakthrough membrane bleeding has not been properly resolved. Recent studies have shown that endometrial vascular structure and dysfunction of the levonorgestrel-releasing intrauterine system caused by irregular bleeding causes, and endometrial angiogenesis and vascular stability-related changes in various factors Its molecular biology, now make a summary.