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目的 研究阿魏酸在不同“证”大鼠体内药动学的差异并初步探索其机制。方法 以高效液相色谱法分析阿魏酸在正常及脾虚血淤大鼠体内的血药浓度 ,同时以放免法检测 3组大鼠血浆及肠道中胃动素和前列腺素E2 含量的变化。结果 阿魏酸在脾虚血淤组大鼠体内的分布容积显著减小 ,消除速率显著降低 ,曲线下面积显著增高 ;多剂量静注阿魏酸后脾虚血淤大鼠血浆和近段空肠组织中胃动素的含量显著下降 ,降结肠和直肠组织中前列腺素E2 的含量显著升高。结论 阿魏酸在正常及血淤证大鼠体内药动学存在差异 ,阿魏酸治疗血淤证作用与调正胃肠激素平衡有关。
Objective To study the difference of pharmacokinetics of ferulic acid in different “syndrome” rats and to explore its mechanism. Methods The plasma concentrations of ferulic acid in normal and spleen deficiency blood stasis rats were determined by HPLC. The contents of motilin and prostaglandin E2 in the plasma and intestine of rats in the three groups were determined by radioimmunoassay. Results The volume of ferulic acid in the spleen deficiency and blood stasis group was significantly reduced, the elimination rate was significantly reduced, and the area under the curve was significantly increased. After multiple doses of intravenous ferulic acid in the spleen and blood stasis rats plasma and proximal jejunum Motilin levels were significantly decreased descending colon and rectal tissue prostaglandin E2 levels were significantly increased. Conclusion Ferulic acid in normal and blood-stasis syndrome in rats pharmacokinetics differences, ferulic acid treatment of blood stasis syndrome and regulate gastrointestinal hormone balance.