凋亡是细胞的程序性死亡,它对多细胞生物个体的发育、维持自身发展平衡以及抵御刺激起着非常关键的作用。大多数情况下,细胞生死主要由Bcl-2家族蛋白的相互作用实现[1]。在哺乳类细胞,抑制凋亡蛋白家族(Bcl-2、Bcl-xL、Bcl-w、Mcl-1、 Apoptosis is a programmed cell death that plays a crucial role in the development of individual multicellular organisms, in maintaining their own balance and in resisting stimuli. In most cases, cell death is mainly mediated by the Bcl-2 family of proteins [1]. In mammalian cells, the family of apoptotic proteins (Bcl-2, Bcl-xL, Bcl-w, Mcl-1,