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1972年瑞典学者 Magnius 和 Espmak 在研究乙型肝炎表面抗原时,发现两个肝炎表面抗原阳性患者的血清中有一条新的沉淀带出现,经过研究与表面抗原决定簇 a、d、y、w、r 均不同,且与核心抗原也不同,而命名为 e 系统,并证明 e 系统不存在于 HBsAg 阴性人血中,随后又有人证明 e 系统持续存在,标志乙型肝炎患者预后不佳,而有传染性。抗—HBe(eAb)存在,则无传染性,预后较好。1977年 Bealsley 提出 eAg、eAb 的分布与 HBsAg 的滴度有关,本文着重探讨 HBsAg 滴度与 eAg 检出率的关系。
In 1972, when Swedish scholars Magnius and Espmak studied hepatitis B surface antigen, they found that a new precipitated band appeared in the sera of two patients with positive hepatitis B surface antigen. After studying the relationship with surface antigenic determinants a, d, y, w, r are different, and with the core antigen is also different, and named e system, and that the e system does not exist in HBsAg negative human blood, followed by evidence that e system persistence, marking the poor prognosis of patients with hepatitis B, and Infectious. Anti-HBe (eAb) exists, then non-infectious, the prognosis is better. In 1977 Bealsley proposed eAg, eAb distribution and HBsAg titer, this article focuses on HBsAg titers and eAg detection rate.