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采用体外液体单层和半固体培养方法,研究小鼠骨髓细胞在受到0、25、50、75、100mGy照射后,骨髓基质祖细胞的形成、特性及功能变化。结果表明:各照射组CFU-F有不同程度增多,50、75mGy组有显著意义;CFU-F基质层对粒系祖细胞集落形成单位(CFU-GM)的支持作用明显增加;CFU-F基质层对骨髓细胞的粘附能力在50、75mGy组有显著提高。结论是骨髓基质祖细胞低剂量照射时具有兴奋效应。
Using in vitro liquid monolayers and semi-solid culture methods, the formation, characteristics and functional changes of bone marrow stromal cells were studied in mice bone marrow cells exposed to 0, 25, 50, 75 and 100 mGy irradiation. The results showed that CFU-F in each irradiation group increased in varying degrees, while 50 and 75mGy groups had significant significance. The CFU-F matrix enhanced the support of CFU-GM. CFU-F matrix The adhesion of the layer to myeloid cells was significantly increased in the 50 and 75 mGy groups. The conclusion is that bone marrow stromal cells have a stimulatory effect at low doses of irradiation.