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目的对两种质子泵抑制剂三联疗法治疗消化性溃疡的效果进行分析。方法将102例消化性溃疡的患者随机分成两组:OCM组51例,口服奥美拉唑胶囊20mg,2次/d;LCM组51例,口服兰索拉唑胶囊30mg,2次/d;两组均加服甲硝唑片0.4g,克拉霉素片1g,2次/d,连服14d后,OCM组改服奥美拉唑胶囊20mg,1次/d;LCM组改服兰索拉唑胶囊30mg,1次/d,其他两种药物剂量、服用方法不变,连服7d,考察治疗效果。结果OCM组21d疗程治愈42例,治愈率为82.35%,5例在加服同类药物1周后痊愈,28d疗程痊愈率为92.16%,随访3个月复发2例,4例在加服同类药物1周未治愈后改服其他药物;LCM组21d疗程治愈48例,治愈率为94.12%。3例在加服同类药物1周后痊愈,28d疗程痊愈率为100%,随访3个月无复发。结论LCM组治疗消化性溃疡效果优于OCM组。
Objective To analyze the effect of triple proton pump inhibitor triple therapy on peptic ulcer. Methods A total of 102 patients with peptic ulcer were randomly divided into two groups: OCM group (n = 51), oral omeprazole capsule (n = 20) twice daily, LCM group (n = 51) and oral lansoprazole capsule Both groups were given metronidazole tablets 0.4g, clarithromycin tablets 1g, 2 times / d, and even served 14d, the OCM group changed to omeprazole capsules 20mg, 1 / d; LCM group to service Lansuo Lazole capsules 30mg, 1 / d, the other two doses of drugs, taking the same method, and even served 7d, study the effect of treatment. Results In the OCM group, 42 cases were cured on the 21d course and the cure rate was 82.35%. Five cases were cured after taking the same drugs for 1 week. The cure rate after 28 days was 92.16%, 2 cases were followed up for 3 months, 4 cases were treated with similar drugs After 1 week untreated change clothes other drugs; LCM group 21d course cured 48 cases, the cure rate was 94.12%. 3 cases in the same drug plus 1 week after the cure, 28d course cure rate was 100%, 3 months follow-up without recurrence. Conclusion LCM group is superior to OCM group in treating peptic ulcer.