论文部分内容阅读
目的探讨肺结核患者血清α1-微球蛋白(α1-MG)及β2-微球蛋白(β2-MG)与结核发生的相关性及其在结核诊断中的意义。方法采用免疫比浊法分别测定118例健康人、125例结核菌阳肺结核以及120例结核菌阴性肺结核患者在规律抗结核治疗前后血清α1-MG及β2-MG含量,统计学采用方差分析方法比较其相应指标的变化,并对相应指标进行单因素相关分析。结果结核菌阳性或结核菌阴性肺结核患者,治疗前后血清α1-MG较健康人组均差异无统计学意义(P>0.05);而治疗前血清β2-MG较健康人组差异有统计学意义(P<0.01),治疗后血清β2-MG较健康人组比较差异无统计学意义(P>0.05)。相关分析结果表明β2-MG与肺结核严重程度呈正相关(相关系数分别为0.876和0.901,P<0.01),α1-MG与肺结核发生无相关性。结论血清β2-MG测定对肺结核诊断有一定参考意义,可以作为肺结核诊断治疗的辅助性监测指标。
Objective To investigate the correlation between serum α1-microglobulin (α1-MG) and β2-microglobulin (β2-MG) and tuberculosis in patients with pulmonary tuberculosis and their significance in the diagnosis of tuberculosis. Methods The levels of serum α1-MG and β2-MG in 118 healthy people, 125 cases of tuberculosis positive pulmonary tuberculosis and 120 cases of tuberculosis negative pulmonary tuberculosis before and after regular anti-TB treatment were measured by immunoturbidimetry. Statistical analysis of variance was used to compare Its corresponding index changes, and the corresponding indicators of single factor correlation analysis. Results There was no significant difference in the serum levels of α1-MG before and after treatment between patients with positive mycobacterium tuberculosis and those with negative pulmonary tuberculosis (P> 0.05), while the serum levels of β2-MG before treatment were significantly different from those in healthy people P <0.01). There was no significant difference in serum β2-MG between the two groups after treatment (P> 0.05). Correlation analysis showed that β2-MG was positively correlated with the severity of pulmonary tuberculosis (correlation coefficients were 0.876 and 0.901 respectively, P <0.01). There was no correlation between α1-MG and pulmonary tuberculosis. Conclusion Serum β2-MG assay has certain reference value for the diagnosis of pulmonary tuberculosis, which can be used as an auxiliary monitoring indicator for the diagnosis and treatment of pulmonary tuberculosis.