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目的研究心力衰竭(简称心衰)患者炎症因子和高凝标志物与其心脏功能和预后的关系。方法对129例心衰患者和40名健康对照组取空腹静脉血,测定血清炎症因子白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6),测定血浆高凝标志物凝血酶抗凝血酶复合物(TAT)、D-二聚体和P-选择素,分析这些指标与心脏功能、心衰病因及生存期的关系。结果心衰患者炎症因子和高凝标志物水平显著高于对照组(P<0.01)。炎症因子和高凝标志物水平与NYHA心脏功能分级和患者的生存期显著相关(均P<0.01),但并未发现与心衰病因有关。结论入院初期炎症因子和高凝标志物水平与心脏功能损伤和患者生存期有关。
Objective To study the relationship between inflammatory factors and hypercoagulable markers and their cardiac function and prognosis in patients with heart failure (HF). Methods Fasting venous blood was collected from 129 patients with heart failure and 40 healthy controls. Serum inflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) were measured. Plasma coagulation markers Thrombin antithrombin complex (TAT), D-dimer and P-selectin, and to analyze the relationship between these indexes and heart function, etiology and survival of heart failure. Results The levels of inflammatory cytokines and hypercoagulability markers in patients with heart failure were significantly higher than those in the control group (P <0.01). The levels of inflammatory markers and hypercoagulability markers were significantly associated with NYHA functional classification and patient survival (P <0.01, respectively), but not with the cause of heart failure. Conclusion The levels of inflammatory factors and hypercoagulability markers in early admission are related to cardiac dysfunction and patient survival.