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皮肤癌在白色人种是最常见的恶性肿瘤,过度暴露阳光是基底细胞癌(BCC′S)、鳞状细胞癌(SCC′S)、也可能是某些恶性黑素瘤的主要病因。紫外光谱中致癌作用最强的部分是紫外光-B(UV-B)波段。紫外光(UVL)致癌作用是一复杂的过程,尚未完全明了,至少涉及两个机制:1.UVL对表皮细胞肿瘤起着促进作用。2.UVL损伤机体对变性表皮细胞的免疫应答功能。用小白鼠实验证实UVL的致癌作用是一个连续的累积过程,可能是固醇通过光化学转换,变成诸如胆固醇-5α、6α-环氧化
Skin cancer is the most common malignancy in white populations. Excess sun exposure is a major cause of basal cell carcinoma (BCC’s), squamous cell carcinoma (SCC’S), and possibly some malignant melanomas. The strongest portion of the UV spectrum is the UV-B (UV-B) band. Ultraviolet light (UVL) carcinogenesis is a complex process that has not yet been fully understood. It involves at least two mechanisms: 1. UVL plays an important role in the promotion of epidermal cell tumors. 2. UVL damage to the immune response function of denatured epidermal cells. The use of white rat experiments confirmed that the carcinogenic effect of UVL is a continuous accumulation process. It may be that sterols undergo photochemical conversion and become such as cholesterol-5α, 6α-epoxidation.