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为了研究大肠癌雌激素受体（ＥＲ）与Ｐ糖蛋白（Ｐｇｐ）表达之间的关系，采用免疫组化法检测６５例大肠癌组织及２１例正常大肠粘膜的ＥＲ及Ｐｇｐ表达情况。大肠癌组织ＥＲ与Ｐｇｐ的表达率分别为７５．４％、７３．８％。ＥＲ及Ｐｇｐ的表达率在大肠组织明显高于相邻正常粘模（Ｐ＜０．０５，Ｐ＜０．０１），不论是大肠癌组织还是正常大肠粘膜，其ＥＲ与Ｐｇｐ的表达无相关性（Ｐ＞０．０５），ＥＲ及Ｐｇｐ表达与患者性别、年龄、肿瘤大小、形态、部位及Ｄｕｋｅｓ′分期均无显著相关。研究表明大肠粘膜在癌变过程中ＥＲ和Ｐｇｐ的表达增加；ＥＲ、Ｐｇｐ作为单一指标尚难判断大肠癌病情及预后。
To investigate the relationship between estrogen receptor (ER) and P glycoprotein (Pgp) expression in colorectal cancer, immunohistochemistry was used to detect the expression of ER and Pgp in 65 cases of colorectal cancer and 21 cases of normal colorectal mucosa. The expression rates of ER and Pgp in colorectal cancer tissues were 75.4% and 73.8%, respectively. The expression rates of ER and Pgp in the large intestine tissue were significantly higher than those in adjacent normal mucosa (P<0.05, P<0.01). Whether it was colorectal cancer tissue or normal colorectal mucosa, there was no correlation between ER and Pgp expression. (P>0.05) There was no significant correlation between ER and Pgp expression and patient gender, age, tumor size, morphology, site, and Dukes’ stage. Studies have shown that the expression of ER and Pgp increased during the carcinogenesis of the large intestine mucosa; ER and Pgp as a single indicator is still difficult to determine the condition and prognosis of colorectal cancer.