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目的 探讨窒息对新生儿胃电活动的影响及普瑞博思的疗效。方法 利用体表胃电图 (EGG)对 5 0例窒息新生儿和 2 0例正常新生儿哺乳前后进行 30min至 1h的胃电活动监测。对胃肠症状明显的 7例窒息儿使用普瑞博思乳剂治疗 7天 ,治疗前后监测EGG。结果 70例新生儿有 39例 (5 6 % )成功记录到EGG。轻度窒息组较对照组哺乳前胃动过缓 [<2周 /分 (cpm) ]百分比增多 ,差别具有统计学意义 (P <0 0 1)。重度窒息组正常慢波百分比较对照组及轻度窒息组明显降低 ,胃动过速 (>4cpm )百分比明显增多 ,P <0 0 1。重度窒息组比轻度组及对照组主频率不稳定系数增高 ,P <0 0 1。普瑞博思治疗后窒息儿胃肠症状消失 ,正常慢波百分比较治疗前增高 ,胃动过速明显减少 ,P <0 0 1。结论 可通过胃电图观察窒息新生儿的胃电活动 ,进而研究新生儿消化道动力 ;围产期窒息的新生儿出现拒乳、腹胀、呕吐等症状 ,可能与其胃电活动异常有关 ;普瑞博思可以再建正常的胃电节律而有效改善窒息儿胃肠症状
Objective To investigate the effect of asphyxia on neonatal gastric electrical activity and the efficacy of pregabs. Methods The EGG was used to monitor the gastric activity of 50 asphyxiating newborns and 20 normal newborns before and after breast feeding for 30 min to 1 h. Seven patients with obvious gastrointestinal symptoms were treated with Puri-Bust emulsion for 7 days and EGG was monitored before and after treatment. Results Thirty-nine newborns (56%) were successfully recorded in EGG. Mild asphyxia group compared with the control group before feeding lactation bradycardia [<2 weeks / min (cpm)] percentage increased, the difference was statistically significant (P <0.01). The percentage of normal slow wave in severe asphyxia group was significantly lower than that in control group and mild asphyxia group, and the percentage of gastric motility tachycardia (> 4 cpm) increased significantly (P <0.01). Severe asphyxia group than the mild group and the control group, the main frequency instability coefficient increased, P <0 01. Pregabas after treatment, gastrointestinal symptoms of asphyxia disappeared, the percentage of normal slow wave increased compared with before treatment, gastric motility was significantly reduced, P <0 01. Conclusion Electrogastrogram can be used to observe the gastric electrical activity in neonates with asphyxia and then to study the motility of the digestive tract in neonates. The symptoms of refusing milk, bloating and vomiting in neonates with perinatal asphyxia may be related to abnormal gastric electrical activities. Booz can rebuild the normal gastric electrical rhythm and effectively improve the gastrointestinal symptoms of suffocation