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为了研究血浆血栓调节蛋白（ＴＭ）水平在冠心病中的意义，采用酶联免疫吸附试验测量５８例冠心病病人的ＴＭ水平。依照冠状动脉造影将病人分成３组：１组为单支病变组；２组为双支病变组；３组为３支及３支以上病变组。结果显示：１、２、３组的ＴＭ水平均比对照组显著增加。１组、２组、３组的ＴＭ水平依次增高，且３组与１组比较具有显著性差异。糖尿病病人的血浆ＴＭ水平显著高于非糖尿病者。结果表明，用血浆可溶性ＴＭ水平评价冠心病病人的内皮细胞损伤程度和范围具有很大价值。
In order to investigate the significance of plasma thrombomodulin (TM) levels in coronary heart disease, enzyme linked immunosorbent assay (ELISA) was used to measure TM levels in 58 patients with coronary heart disease. According to coronary angiography, the patients were divided into 3 groups: group 1 was a single lesion group; group 2 was a double-vessel lesion group; group 3 was 3 and more than 3 lesion groups. The results showed: TM group 1, 2, 3 were significantly higher than the control group. The levels of TM in group 1, group 2 and group 3 increased successively, and there was a significant difference between group 3 and group 1. Plasma levels of TM in diabetic patients are significantly higher than those in non-diabetic patients. The results show that the use of plasma soluble TM levels in patients with coronary heart disease evaluation of the extent and extent of endothelial cells of great value.