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用消炎痛和氯丙嗪作阻断剂，以子宫收缩曲线下面积（UCA）为指标，分析怀牛膝皂甙A对大鼠离体子宫兴奋作用的机理。结果表明，实验前给大鼠用消炎痛（75mg／只）灌胃或浴槽内加消炎痛（20mg／L），均可明显减弱怀牛膝皂甙A对大鼠离体子宫的兴奋作用。氯丙嗪（0．5mg／L）也可明显减弱怀牛膝皂甙A对未孕、已孕大鼠离体子宫的兴奋作用。提示怀牛膝皂甙A的子宫兴奋作用可能与5－HT及PG的合成与释放有关。
Using indomethacin and chlorpromazine as blocking agents, the area under the Uterine Contraction Curve (UCA) was used as an index to analyze the mechanism of the effect of Achyranthes bidentata A on excitability of isolated rat uterus. The results showed that pre-experimental administration of indomethacin (75 mg/bodily) to rats or intubation plus indomethacin (20 mg/L) before the experiment significantly attenuated the stimulant effect of Huaiyin and Astragaloside A on isolated rat uterus. Chlorpromazine (0.5 mg/L) also significantly attenuated the stimulant effect of Huaiyin BJS A on the uterus of pregnant and pregnant rats. It is suggested that the uterus excitability of Achyranthes bidentata A may be related to the synthesis and release of 5-HT and PG.