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小鼠白血病细胞L7811—85细胞系在体外可形成克隆,体内接种可使小鼠100％致病。本文利用这个细胞系比较了三种体外细胞毒检测法—中期培养拒染法、[~3H]TdR参入抑制法和克隆形成测定法用于化疗药物药效敏感性的观察,并与体内接种瘤细胞后的动物生存期延长的疗效进行比较。
Mouse leukemia cells L7811-85 cell lines can form clones in vitro, in vivo vaccination mice can be 100% pathogenic. In this paper, we compared three cytotoxicity assays in vitro - metaphase culture, [~ 3H] TdR incorporation inhibition and clonogenic assay for the chemosensitivity of chemotherapeutic drugs, and compared with in vivo tumor inoculation Cell survival was prolonged after the animals were compared.