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目的探讨甘精胰岛素联合格列吡嗪治疗2型糖尿病的临床效果。方法选取射阳县人民医院2015年1月—2016年2月收治的2型糖尿病患者70例,按照随机数字表法分为对照组和观察组,各35例。患者入院后均给予对症处理,对照组患者给予甘精胰岛素联合盐酸二甲双胍片治疗,观察组患者给予甘精胰岛素联合格列吡嗪片治疗,两组患者均持续治疗12周。比较两组患者的临床疗效,治疗前后空腹血糖、餐后2h血糖,并观察比较两组患者治疗期间不良反应发生情况。结果观察组患者治疗总有效率高于对照组(P<0.05)。治疗前,两组患者空腹血糖、餐后2h血糖比较,差异无统计学意义(P>0.05);治疗后,观察组患者空腹血糖、餐后2h血糖低于对照组(P<0.05)。观察组患者治疗期间不良反应发生率低于对照组(P<0.05)。结论皮下注射甘精胰岛素联合口服格列吡嗪片治疗2型糖尿病疗效确切,可有效降低患者血糖水平,且不良反应少。
Objective To investigate the clinical effects of glargine and glipizide in the treatment of type 2 diabetes. Methods Seventy patients with type 2 diabetes who were treated in Sheyang County People’s Hospital from January 2015 to February 2016 were randomly divided into control group and observation group according to random number table. All patients were given symptomatic treatment after admission. Patients in the control group were treated with insulin glargine and metformin hydrochloride tablets, and patients in the observation group were given insulin glargine and glipizide tablets. Both groups were treated for 12 weeks. The clinical efficacy, fasting blood glucose before and after treatment, and postprandial blood glucose at 2h were compared between the two groups. The occurrence of adverse reactions in the two groups were observed and compared. Results The total effective rate of observation group was higher than that of control group (P <0.05). Before treatment, there was no significant difference in fasting blood glucose and postprandial 2h blood glucose between the two groups (P> 0.05). After treatment, fasting blood glucose and postprandial 2h blood glucose were lower in the observation group than in the control group (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group (P <0.05). Conclusion Subcutaneous glargine plus oral glipizide tablets for the treatment of type 2 diabetes mellitus is effective and can effectively reduce the blood sugar level of patients with less adverse reactions.