论文部分内容阅读
目的研究2型糖尿病肾病与C反应蛋白、白细胞介素-6、瘦素的关系。方法尿微量白蛋白排除率<20μg/min者32例为Ⅰ组,尿微量白蛋白排泄率20-200μg/min者29例为Ⅱ组,尿微量白蛋白>200μg/min者28例为Ⅲ组,测定伴有不同程度尿微量白蛋白的2型糖尿病患者的C反应蛋白(CRP)、白细胞介素-6(IL-6)、瘦素(LEP)的含量。结果Ⅲ组、Ⅱ组CRP、IL-6、LEP的含量高于Ⅰ组的糖尿病病人(P<0.01,P<0.05),Ⅲ组糖尿病病人其CRP、LP-6、LEP的含量也高于Ⅱ组患者(P<0.01,P<0.05)。结论2型糖尿病肾病患者早期即存在炎症因子及瘦素地增高。血清超敏CRP、IL-6、LEP的测定可作为判断2型糖尿病肾损害程度及预后的指标。
Objective To study the relationship between type 2 diabetic nephropathy and C-reactive protein, interleukin-6 and leptin. Methods: The urinary albumin excretion rate was less than 20μg / min in 32 patients in group Ⅰ, urinary albumin excretion rate was 20-200μg / min in 29 patients in group Ⅱ, and urine microalbumin> 200μg / min in 28 patients in group Ⅲ (CRP), interleukin-6 (IL-6) and leptin (LEP) in patients with type 2 diabetes mellitus with varying degrees of microalbuminuria were measured. Results The levels of CRP, IL-6 and LEP in group Ⅲ and group Ⅱ were higher than those in group Ⅰ (P <0.01, P <0.05). The levels of CRP, LP-6 and LEP in group Ⅲ were also higher than those in group Ⅱ Group patients (P <0.01, P <0.05). Conclusion There are inflammatory factors and leptin in patients with type 2 diabetic nephropathy. Determination of serum hypersensitive CRP, IL-6, LEP can be used as indicators to determine the extent of type 2 diabetic renal damage and prognosis.