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目的观察妊娠合并子宫肌瘤红色变性患者行剖宫产及剔除肌瘤围术期小剂量肝素辅治对血清Ang-2及VEGF的影响。方法将232例妊娠并子宫肌瘤红色变性患者随机分为试验组和对照组各116例。2组患者分娩前均给予小剂量肝素治疗,试验组采取剖宫产并剔除术,对照组根据患者意愿和条件自然分娩或剖宫产,不切除子宫肌瘤。观察肝素治疗前、治疗后24h和分娩后血清血管生成素2(Ang-2)及血管内皮生长因子(VEGF)差异。结果 2组患者肝素治疗前血清Ang-2和VEGF水平相近,差异均无统计学意义(P>0.05);肝素治疗后24h 2组患者血清检测值均有轻度降低,但差异均无统计学意义(P>0.05)。2组患者分娩后血清检测值进一步降低,且试验组血清指标降低幅度明显大于对照组,差异有统计学意义(P<0.05)。结论小剂量肝素辅助剖宫产并剔除术治疗妊娠并子宫肌瘤红色变性可有效恢复患者血清Ang-2和VEGF水平。
Objective To observe the effect of low-dose heparin on the serum Ang-2 and VEGF levels in patients with red degeneration of uterine fibroids during pregnancy and cesarean section. Methods 232 cases of pregnant women with red degeneration of uterine fibroids were randomly divided into experimental group and control group of 116 cases. Two groups of patients were given low-dose heparin before delivery. The cesarean section was taken out in the test group. The control group was given spontaneous labor or cesarean section according to the patients’ wishes and conditions. The uterine fibroids were not removed. The differences of serum Angiopoietin 2 (Ang-2) and vascular endothelial growth factor (VEGF) before and 24 hours after delivery and after delivery were observed. Results The serum levels of Ang-2 and VEGF in heparin before treatment in both groups were similar (P> 0.05), but the serum levels in 24h group were slightly decreased after heparin treatment, but the differences were not statistically significant Significance (P> 0.05). Serum detection values of the two groups of patients were further reduced after delivery, and the decrease of serum indexes in the experimental group was significantly greater than that in the control group (P <0.05). Conclusion Low-dose heparin assisted cesarean section and excision of pregnancy and uterine fibroids red degeneration can effectively restore the serum levels of Ang-2 and VEGF.