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目的对莫西沙星治疗老年耐多药肺结核患者的临床效果进行有效的研究。方法 100例耐多药肺结核老年患者,随机分为对照组与观察组,各50例。对照组采用3DEZTV/9DZTV的治疗方法 ,观察组采用3DEZTM/9DZTM的治疗方法 ,治疗12个月后对两组患者的X线与痰菌转阴情况进行分析。结果观察组病变好转率达95%,对照组病变好转率达92%,比较差异无统计学意义(P>0.05);观察组空洞好转54%(27/50),对照组空洞率好转30%(15/50),比较差异无统计学意义(P>0.05)。观察组痰菌转阴率达96%,对照组痰菌转阴率达78%;观察组总疗效率达98%,对照组达84%,两组痰菌转阴率及总有效率比较差异均具有统计学意义(P<0.05)。结论通过对老年耐多药肺结核患者使用莫西沙星治疗,临床效果显著,有效提高患者的痰菌转阴率,应得到大力的推广与应用。
Objective To investigate the clinical efficacy of moxifloxacin in the treatment of elderly patients with multi-drug resistant pulmonary tuberculosis. Methods 100 elderly patients with MDR-TB were randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with 3DEZTV / 9DZTV, and the observation group was treated with 3DEZTM / 9DZTM. After 12 months of treatment, the X-ray and sputum negative conversion of the two groups were analyzed. Results The improvement rate of disease in the observation group was 95%, and the improvement rate of the disease in the control group was 92% (P> 0.05). The improvement rate of the hole in the observation group was 54% (27/50) (15/50), the difference was not statistically significant (P> 0.05). In the observation group, the negative rate of sputum bacteria was 96% and that of the control group was 78%. The total effective rate was 98% in the observation group and 84% in the control group. The negative conversion rate and the total effective rate All were statistically significant (P <0.05). Conclusion The treatment of moxifloxacin in elderly MDR-TB patients has significant clinical effect and effectively improves the rate of sputum negative conversion rate in patients, which should be vigorously popularized and applied.