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近来维生素D的骨外效应受到关注。除参与传统的钙磷代谢外,维生素D还具有广泛的生物学效应,进而可影响多种疾病的发病和进展。研究发现,维生素D具有调节免疫炎症过程,影响胰岛素的分泌和外周效应的作用;当体内维生素D缺乏时,免疫炎症细胞,胰岛β细胞以及胰岛素靶细胞功能将受到不同程度损害,由此导致的免疫紊乱、全身性炎症反应以及胰岛素的分泌和作用障碍均可能在糖尿病及其相关的糖代谢异常中发挥重要作用。
Recently, the extravitaminar effect of vitamin D has drawn attention. In addition to participating in traditional calcium and phosphorus metabolism, vitamin D also has a wide range of biological effects, which can affect the incidence and progression of many diseases. The study found that vitamin D has the role of regulating the process of immune inflammation, affecting insulin secretion and peripheral effects; when the body of vitamin D deficiency, immune inflammatory cells, pancreatic β cells and insulin target cell function will be different degrees of damage, resulting in Immune disorders, systemic inflammatory response, and insulin secretion and dysfunction may play important roles in the pathogenesis of diabetes and its associated abnormal glucose metabolism.