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目的研究乌鲁木齐5岁以下儿童在接种乙肝疫苗(Hepatitis B Vaccine,HepB)后出现无(弱)应答的影响因素。方法按性别、年龄、民族1∶1配对原则,选取279对无(弱)应答者病例和对照,采用多因素条件Logistic回归分析父母健康状况,疫苗接种剂量、种类、部位、次数以及药物摄入、饮食等因素与无(弱)应答发生的关系。结果多因素条件Logistic回归分析显示与无(弱)应答有关的因素为母亲HBsAg阳性、母亲HBsAb阳性、父亲HBsAg阳性、父亲HBsAb阳性、父亲有HepB免疫无应答史,其OR值分别为4.467、0.879、5.768、0.881、6.020,其中父亲HBsAb阳性、婴儿餐具进行消毒,出生当日接种疫苗是儿童体内产生HBsAb的保护因素。结论父母亲为HBV携带者是儿童在接种乙肝疫苗后发生无(弱)应答的危险因素,而父母亲体内有HBsAb是儿童在接种乙肝疫苗后产生应答的保护因素。
Objective To investigate the influencing factors of no (weak) response in children under 5 years of age after vaccination with Hepatitis B Vaccine (HepB) in Urumqi. Methods According to the principle of 1: 1 sex, age and ethnicity, 279 pairs of no (weak) responders and controls were selected. Multivariate Logistic regression analysis was used to analyze the health status of parents, the dose, type, location, frequency of drug ingestion , Diet and other factors with no (weak) response to the relationship. Results Multivariate conditional logistic regression analysis showed that the factors related to no (weak) response were mothers with HBsAg positive, mothers HBsAb positive, fathers HBsAg positive, fathers HBsAb positive and fathers with HepB immune unresponsiveness, with ORs of 4.467 and 0.879 , 5.768,0.881,6.020, of which HBsAb positive father, baby tableware disinfection, vaccination on the day of birth is a protective factor in children’s HBsAb. Conclusions Parents who are carriers of HBV are the risk factors for non-(weak) response of children to hepatitis B vaccine. The parental HBsAb is the protective factor of children’s response to hepatitis B vaccine.