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目的探讨家族性非髓样甲状腺癌的遗传学、诊断及诊疗,为其早期诊断及正确治疗提供依据。方法总结家族性非髓样甲状腺癌患者的临床资料,对其遗传学、早期诊断及治疗等方面进行探讨。结果家族性非髓样甲状腺癌起源于甲状腺滤泡上皮细胞,它单独发生或作为家族性肿瘤综合征发生。多发性病灶和同时伴发腺瘤性甲状腺肿是其特征性临床表现,并且多发生在年轻人;合理的手术治疗可以取得满意的疗效。结论家族性非髓样甲状腺癌是一种遗传性疾病,早期诊断、合理的手术治疗可以取得满意的疗效。患者家族成员应长期随访。
Objective To investigate the genetics, diagnosis and diagnosis of familial non-myeloid thyroid carcinoma and provide the basis for their early diagnosis and correct treatment. Methods The clinical data of patients with familial non-myeloid thyroid carcinoma were summarized and their genetics, early diagnosis and treatment were discussed. Results Familial non-myeloid thyroid carcinoma originated in thyroid follicular epithelial cells, which occurs either alone or as a familial tumor syndrome. Multiple lesions and concomitant adenomatous goiter is its characteristic clinical manifestations, and occurs in young people; reasonable surgical treatment can achieve satisfactory results. Conclusion Familial non-myeloid thyroid cancer is a genetic disease, early diagnosis and reasonable surgical treatment can achieve satisfactory results. Patients should be long-term follow-up.