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目的研究细胞免疫功能和细胞因子白细胞介素6(IL－6)在创伤及修复过程中的作用与临床的关系.方法观察14例重度和28例轻度创伤患者T细胞体外培养增殖反应、T细胞亚群的变化与IL－6的表达.结果57.14％的重度创伤患者T细胞增殖反应减弱,IL－6的表达受到抑制,T细胞体外培养液中IL－6含量降低为82.36PG/ML,而轻度创伤和健康对照组分别为183.07PG/ML和472.90PG/ML,其差异有非常显著性意义.重度创伤患者CD8+细胞数量相对增加,百分率增高为33.43％,使CD4+/CD8+比值下降(158),明显低于轻度创伤(1.73)和健康对照组(1.76),差异有显著性意义.细胞培养液中IL－6的含量与CD8+细胞数量呈负相关(R＝－0.438).结论在重度创伤患者CD8+细胞数相对增多时,可抑制T细胞的增殖能力,并伴有T细胞体外培养IL－6表达作用的减弱.“,”Objective TO study the cellullar immunity function and the role of interleukin-6(IL - 6) during trauma and its recovery stage. Methods 14 cases of serious and 28 mild traumatic fractureswere selected to observe the change of T cell proliferation reaction and IL - 6 presentation of concentration inthe liqUid of T cell culture in vitro. Results 57.14% of serious cases presented the depression of cellproliferation, and IL - 6 concentration reduced to 82. 36 pg/ml, which was lower than that in mild traumagroup (183. 07 pg/ml) and control group(472. 90 pg/ml) respectively. There is statistical significance between the two groups. The rate of CD 8 + T cell was increased relatively in the serious group (33. 43% ), andthe ratio of CD 4 + /CD 8 + (1.58 ) was lower than the group of mild trauma (1. 73 ) and control group (1. 76).There is negative relationship between the concentration of IL - 6 in cell proliferation liquid and CD 8 + T cellratio (r = - 0. 438) in those cases. ConcluSion in serious cases, the T cell proliferation was depressed,while the number of CD 8+ cell increased relatively, and IL - 6 expression was decreased.