急性缺氧对大鼠血浆ANP浓度的影响这一工作目前尚未见报道,关于ANP的释放机制,虽然前人已证实了心房压力升高的作用,但还缺乏深入系统的研究。本实验旨在于了解急性缺氧对大鼠血浆ANP浓度的影响及其可能的机制。实验用wistar大鼠(♂),300～380g,腹腔注射2％戊巴比妥钠麻醉,在开胸正压人工呼吸下,采用心脏直接插管法测定心室压力及心房压力。血浆及心房ANP浓度的测定采用放射免疫法(301医院产的药盒)。各组样品按随机交叉 Acute hypoxia on plasma ANP concentration in this work has not been reported, on the release mechanism of ANP, although previous studies have confirmed the role of atrial pressure, but the lack of in-depth systematic study. The purpose of this experiment is to understand the effect of acute hypoxia on plasma ANP concentration in rats and its possible mechanism. Experimental wistar rats (♂), 300 ~ 380g, intraperitoneal injection of 2% sodium pentobarbital anesthesia, chest open pressure artificial respiration, the use of direct cardiac catheterization ventricular pressure and atrial pressure measurements. Plasma and atrial ANP concentrations were measured by radioimmunoassay (301 Hospital kit). Samples of each group randomly cross