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背景:红景天具有抗衰老、抗疲劳、提高人体免疫力的作用,并可缓解心绞痛。目的:研究红景天对心脏的血液动力学及心肌收缩力的影响,并探讨其机制。设计:以实验动物为研究对象的观察对比研究。单位:一所医科大学的生理学教研室。材料:实验于2001-01/2001-04在广西医科大学生理学教研室心血管研究实验室进行。新西兰大白兔30只,雌雄不限,体质量1.9～2.3kg,随机分为2组,对照组(生理盐水4mL/kg)和红景天(诺迪康)组(0.5g/4mL·kg),每组15只。普通野生青蛙100只,体质量-1120～160g,随机分为4组,即生理盐水对照组、诺迪康小剂量组(血药浓度209mg/L)、诺迪康中剂量组血药浓度418mg/L)和诺迪康大剂(量组(血药浓度627mg/L),每组25只。方法:运用ms2000多媒体生物信号分析系统,经Straub法制备离体蛙心灌流标本并检测心脏活动,利用血液动力学方法检测大白兔的心室活动等相关指标。主要观察指标:两组家兔心脏血液动力学变化的比较,不同剂量诺迪康对离体蛙心工作影响的比较。结果:各诺迪康组的心肌收缩力比对照组的明显增强(F=8.939,P<0.01),209,418,627mg/L诺迪康组的心肌收缩力呈现递增趋势,分别增强52.3%,70.1%,86.4%,但各实验组间未达显著差异(P>0.05);各组之间的蛙心心率也无显著性差异(P>0.05)。大白兔血液动力学?
Background: Rhodiola has anti-aging, anti-fatigue, and immune-boosting effects, and can relieve angina. Objective: To study the effect of Rhodiola on the hemodynamics and myocardial contractility of the heart, and to explore its mechanism. Design: An observational comparison study of experimental animals. Unit: Department of Physiology, Medical University. MATERIALS: The experiment was performed at the cardiovascular research laboratory of the Department of Physiology, Guangxi Medical University from January 2001 to April 2001. Thirty New Zealand white rabbits, male or female, weighing 1.9 to 2.3 kg, were randomly divided into 2 groups, control group (normal saline 4 mL/kg) and Rhodiola (Noriticon) group (0.5 g/4 mL·kg) , 15 per group. One hundred common wild frogs weighing from -1120 to 160 g were randomly divided into 4 groups: normal saline control group, low-dose Norbutamol group (blood concentration of 209 mg/L), and middling dose of nordicak plasma concentration of 418 mg. (L/) and Nocardiac agent (amount of drug (627 mg/L in blood)), 25 mice in each group Methods: Preparation of isolated frog heart perfusion specimens and detection of cardiac activity using the Straub method using the ms2000 multimedia biosignal analysis system The use of hemodynamic methods to detect ventricular activity and other related indicators in rabbits.The main observation indicators: the comparison of cardiac hemodynamic changes between two groups of rabbits, the effects of different doses of Noritik on the impact of isolated frog heart work. In the Nocardik group, the myocardial contractility was significantly higher than that in the control group (F=8.939, P<0.01). The myocardial contractility of the 209,418, 627 mg/L Noriticon group showed an increasing trend, which was increased by 52.3%, 70.1%, and 86.4%, respectively. However, there was no significant difference among the experimental groups (P>0.05), and there was no significant difference in frog heart rate among the groups (P>0.05).