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许多可以做为肿瘤细胞标记的酶和组织抗元,在肝细胞癌中已被证实。我们已指出:人类肝细胞癌,其抗元(如;aI抗胰蛋白酶、甲胎蛋白、癌胚抗元和乙型肝炎表面抗元)的表现形式,有明显的多相性。许多研究者,根据其对动物肝细胞癌模型的观察,指出:癌前病变和癌细胞皆有不同酶的表型异质。这些酶包括:胆小管三磷酸腺苷酶(ATPase)、6—磷酸葡萄糖酶(G6Pase)和—谷氨酰转肽酶(GGTPase)。在增生性和肿瘤性肝细胞中,前二种酶的活性常降低,而后一种酶的活性增高。据我们所知,动物肝细胞癌酶型变化
Many enzymes and tissue antigens that can serve as tumor cell markers have been confirmed in hepatocellular carcinoma. We have pointed out that human hepatocellular carcinoma, its anti-yuan (such as; aI antitrypsin, alpha-fetoprotein, carcinoembryonic antigen and hepatitis B surface antigen) manifestations, there is obvious heterogeneity. Many researchers, according to their observation of animal models of hepatocellular carcinoma, pointed out that precancerous lesions and cancer cells have different enzyme phenotypic heterogeneity. These enzymes include: ATPase, G6Pase, and GGTPase. In proliferative and neoplastic hepatocytes, the activity of the first two enzymes often decreases, while the activity of the latter enzyme increases. As far as we know, the enzyme-type changes of animal hepatocellular carcinoma