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目的 :探讨 2型糖尿病患者骨密度 (BMD)、肿瘤坏死因子 α(TNF α)和一氧化氮 (NO)变化及其TNF α和NO与BMD的关系。方法 :观察 2型糖尿病组、正常对照组BMD、TNF α和NO的变化并进行比较 ,分析 2型糖尿病组中TNF α和NO与BMD的关系。结果 :2型糖尿病患者的BMD低于对照组 ,TNF α、NO水平高于对照组 ;2型糖尿病患者TNF α、NO水平与BMD呈显著的负相关 ,TNF α与NO呈正相关。结论 :2型糖尿病患者的BMD降低 ,TNF α和NO在其中起重要作用。
Objective: To investigate the changes of bone mineral density (BMD), tumor necrosis factor α (TNF α) and nitric oxide (NO) and the relationship between TNF α, NO and BMD in type 2 diabetic patients. Methods: The changes of BMD, TNFα and NO in type 2 diabetes mellitus group and normal control group were observed and compared, and the relationship between TNFα, NO and BMD in type 2 diabetes mellitus was analyzed. Results: The BMD in patients with type 2 diabetes mellitus was lower than that in controls, and the levels of TNFα and NO were higher than those in controls. The levels of TNFα and NO in type 2 diabetes patients were negatively correlated with those in patients with type 2 diabetes. The levels of TNFα and NO were positively correlated. Conclusion: BMD in type 2 diabetic patients is decreased, and TNFα and NO play an important role.