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为探讨克拉瑞啶对急性脑梗塞的治疗效果与机理。69例经临床和脑CT扫描/MRI确诊的急性脑梗塞患者被随机分为克拉瑞啶治疗组(46例)和低分子右旋糖酐对照组(23例)。二组患者均于治疗前和治疗后1个月做神经功能缺损评分,结合治疗后患者的病残程度,评定临床疗效;同时做血液流变学检测。结果克拉瑞啶治疗急性脑梗塞总有效率为84.8%,明显高于对照组(65.2%,P<0.01)。且能明显降低患者血浆粘度,全血低切粘度及红细胞聚集指数。提示克拉瑞啶治疗急性脑梗塞安全、有效。
To investigate the effect and mechanism of Clariidine on acute cerebral infarction. Sixty-nine patients with acute cerebral infarction confirmed by clinical and brain CT scan / MRI were randomly divided into clarithromycin treatment group (46 cases) and low molecular weight dextran control group (23 cases). Two groups of patients before treatment and 1 month after treatment to make neurological deficit score, combined with the patient’s degree of sick after treatment, to assess the clinical efficacy; at the same time to do the blood rheology test. Results The total effective rate of the treatment of acute cerebral infarction with clarithromycin was 84.8%, which was significantly higher than that of the control group (65.2%, P <0.01). And can significantly reduce the patient’s plasma viscosity, low blood viscosity and erythrocyte aggregation index. Tip Clariidine safe and effective treatment of acute cerebral infarction.