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目的探讨米托蒽醌 (MTZ)膀胱灌注防止术后复发的疗效和安全性。方法对 5 8例膀胱癌患者行膀胱部分切除术。术后定期应用MTZ膀胱内灌注 ,每次药物在膀膀胱内保留 2小时。结果 5 8例均未见全身药物不良反应 ,仅 7例出现轻微膀胱刺激症状。随访 3～ 2 4个月 ,复发 5例 ,复发率 8.6 %。结论MTZ膀胱灌注预防膀胱癌术后复发疗效满意 ,副作用小 ,安全性好。
Objective To investigate the curative effect and safety of intravesical instillation of mitoxantrone (MTZ) in preventing postoperative recurrence. Methods Fifty-eight patients with bladder cancer underwent partial bladder resection. MTZ intravesical instillation was performed periodically after surgery, and each drug was retained in bladder for 2 hours. Results No systemic adverse drug reactions were found in 58 cases, and only slight irritation of bladder was found in only 7 cases. Followed up for 3 ~ 24 months, 5 cases were relapsed, the recurrence rate was 8.6%. Conclusions MTZ intravesical instillation is effective in preventing postoperative recurrence of bladder cancer with small side effects and good safety.