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目的 探讨米索前列醇 (简称米索 )足月妊娠引产的最佳给药途径。方法 对 10 8例足月妊娠、单胎头位、无阴道分娩禁忌症者 ,随机分为两组 :米索口服组 5 5例 ,米索阴道组 5 3例 ,分别用米索 2 5mg口服与阴道置药 ,3～ 4h无效后重复给药 ,4 8h为一疗程 ,总量不超 2 0 0ug。比较两组不同途径给药的引产成功率 ,总产程、分娩方式、急产发生率、剖宫产率、产后两小时出血量、新生儿窒息发生率。结果 ,米索口服引产成功率为 94 5 5 %,高于米索阴道组 79 2 5 %(P <0 .0 5 ) ;阴道组总产程显著较口服组短 (P <0 .0 1) ,阴道组急产发生率 2 1 4 2 %,高于口服组 1 96 %(P <0 .0 1) ,阴道组剖宫率 2 2 6 4 %,显著高于口服组 7 2 7%(P >0 .0 5 )。两组产后出血量 ,新生儿窒息发生率均无明显差异 (P <0 .0 5 )。结论 小剂量米索 (2 5ug)口服用于足月妊娠引产是一种简便、易行、安全有效的给药最佳途径。
Objective To explore the optimal route of administration of misoprostol (misoprostol) term pregnancy induced labor. Methods One hundred and eighty contraceptives with full-term pregnancy, single head and no vaginal delivery were randomly divided into two groups: 54 cases in the misoprostol group and 53 cases in the misoprostol group. The patients were treated with 25 mg misoprostol And vaginal medicine, 3 ~ 4h invalid after repeated administration, 48h for a course of treatment, the total does not exceed 200ug. The success rate of induction of labor, total labor, mode of delivery, rate of emergency labor, cesarean section rate, amount of bleeding after two hours of delivery and incidence of neonatal asphyxia were compared between the two groups. As a result, the success rate of misoprostol induction of labor was 94.55%, which was higher than that of misoprostol group 79.25% (P <0.05). The total vaginal delivery was significantly shorter (P <0.01) (P <0.01). The rate of emergency in vaginal group was 21.42%, which was higher than that in oral group (96%, P <0.01). The rate of cesarean section in vaginal group was 22.4%, significantly higher than that in oral group P> 0 .0 5). There was no significant difference in postpartum hemorrhage volume and neonatal asphyxia between the two groups (P <0.05). Conclusions Oral administration of low dose misoprostol (2 5 ug) for full-term pregnancy induced abortion is a convenient, safe and effective route of administration.