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目的探讨消化性溃疡出血应用不同剂量质子泵抑制剂治疗的临床效果。方法回顾分析60例患者的临床资料。结果对照组15例中,显效8例,有效3例,无效4例;低剂量组15例中,显效9例,有效4例,无效2例;中剂量组15例中,显效10例,有效4例,无效1例;高剂量组15例中,显效12例,有效3例。结论消化性溃疡出血时,溃疡黏膜中的纤维蛋白溶解活性显著增强,从而使血凝块易于溶解。奥美拉唑治疗消化性溃疡出血,是一种高效、安全的抑酸剂,值得临床应用。
Objective To investigate the clinical effect of proton pump inhibitor with different doses of peptic ulcer bleeding. Methods The clinical data of 60 patients were retrospectively analyzed. Results Among 15 cases in control group, 8 cases were markedly effective, 3 cases were effective and 4 cases were ineffective. Among 15 cases in low dose group, 9 cases were markedly effective, 4 cases were effective and 2 cases were ineffective. Among 15 cases in middle dose group, 10 cases were markedly effective 4 cases, 1 case of ineffective; high-dose group of 15 cases, markedly effective in 12 cases, effective in 3 cases. Conclusions Peptic ulcer hemorrhage, fibrinolytic activity of ulcer mucosa significantly increased, so that the clot is easy to dissolve. Omeprazole treatment of peptic ulcer bleeding, is an efficient and safe acid suppressant, it is worth clinical application.