目的:评估灵活、低剂量促性腺激素释放激素拮抗剂(Gn RH-A)方案和标准的Gn RH-A方案在卵巢储备功能减退患者体外受精-胚胎移植(IVF-ET)/卵胞质单精子注射(ICSI)的超促排卵过程中的应用价值。方法:回顾性分析108例卵巢储备功能减退患者IVF-ET周期,其中58例使用灵活而低剂量Gn RH-A方案(A组),50例使用标准Gn RH-A方案(B组)。比较各组实验室指标和临床结局。结果:A组Gn RH-A使用天数、剂量均少于B组(P<0.05);A组h CG注射日E2峰值、优质胚胎数、新鲜胚胎移植周期临床妊娠率、累积临床妊娠率均高于B组(P<0.05);但促排卵天数、Gn用量、内膜厚度、获卵数、成熟卵数、受精率、新鲜胚胎移植周期移植胚胎数、冻融胚胎移植周期临床妊娠率、累积着床率组间无统计学差异(P>0.05)。结论:与标准Gn RH-A方案相比,灵活而低剂量的Gn RH-A使用方案可获得更多的优质胚胎并降低Gn RH-A的使用总剂量和天数,提高累积临床妊娠率和胚胎着床率。 OBJECTIVE: To evaluate the efficacy of the flexible, low-dose gonadotropin-releasing hormone antagonist (Gn RH-A) regimen and the standard Gn RH-A regimen in in vitro fertilization-embryo transfer (IVF-ET) / oocyte cytoplasmic sperm The value of injection (ICSI) in the process of superovulation. Methods: A retrospective analysis of 108 patients with ovarian reserve dysfunction in patients with IVF-ET cycle, of which 58 patients with flexible and low-dose Gn RH-A regimen (group A), 50 patients with standard Gn RH-A regimen (group B). Compare each group laboratory index and clinical outcome. Results: The days of Gn RH-A administration in group A were shorter than those in group B (P <0.05). The peak E2 of E2, the number of high quality embryos, the clinical pregnancy rate and the cumulative clinical pregnancy rate of group A were higher (P <0.05). However, the number of days of ovulation, the amount of Gn, the thickness of the intima, the number of oocytes retrieved, the number of mature eggs, the fertilization rate, the number of embryos transferred in the fresh embryo transfer cycle, the clinical pregnancy rate in the period of the freeze-thawed embryo transfer, There was no significant difference between implantation rates (P> 0.05). CONCLUSIONS: The use of flexible and low-dose Gn RH-A regimen results in more quality embryos and lower total Gn RH-A dose and days used compared to the standard Gn RH-A regimen, increasing cumulative clinical pregnancy rates and embryos Implantation rate.