论文部分内容阅读
目的比较简化MDRD方程(eGFRa)、中国方程(c-aGFR3)、瑞金方程(M-MDRD-GFR)及CKD-EPI公式对60岁以上人群肾功能的评估价值。方法选取江苏两地1404名60-94岁常住居民,分为三个年龄组和三个合并症按上述方法测定肾小球滤过率(GFR),评价其与年龄的相关性,比较各方程测量肾功能的差异。结果 CKD-EPI公式计算GFR值随增龄而下降(P<0.01)。在60岁以上高血压、糖尿病及高尿酸血症人群中较低。中国方程、瑞金方程和CKD-EPI公式计算得到的高尿酸血症人群GFR值低于健康人群。中国方程、瑞金方程、CKD-EPI公式与简化MDRD方程的一致性检验Kappa值分别为0.775、0.883、0.912(P<0.01)。CKD-EPI公式与简化MDRD公式的相关性最好、偏差最小、符合率最高。结论在江苏省60岁以上人群,各种方法计算GFR值均有随增龄呈下降的趋势,CKD-EPI公式可能是比较优选的GFR评估公式。
Objective To evaluate the renal function of patients over 60 years old by comparing simplified MDRD equation (eGFRa), Chinese equation (c-aGFR3), M-MDRD-GFR and CKD-EPI formula. Methods A total of 1404 residents aged 60-94 in Jiangsu were selected and divided into three age groups and three comorbidities. The GFR was measured by the above method to evaluate the correlation with age. Measurement of differences in renal function. Results CKD-EPI formula calculated GFR decreased with age (P <0.01). Lower in people over 60 years old with hypertension, diabetes and hyperuricemia. The GFR of hyperuricemia population calculated by the Chinese equation, the Ruijin equation and the CKD-EPI formula is lower than that of the healthy population. The Kappa values of the Chinese equation, the Ruijin equation, the CKD-EPI formula and the simplified MDRD equation were 0.775, 0.883 and 0.912, respectively (P <0.01). The correlation between CKD-EPI formula and simplified MDRD formula is the best, with the least deviation and the highest coincidence rate. Conclusions The GFR values calculated by various methods tend to decrease with age over the age of 60 in Jiangsu Province. The CKD-EPI formula may be the preferred GFR evaluation formula.