金黄色葡萄球菌既是一种短暂的皮肤寄居者,也是一种可怕的人类病原体,主要可引发机体皮肤和软组织感染以及严重的肺炎;如今科学家们尝试了很多种策略来抵御这种病原体,然而大量的细菌都会对抗生素疗法产生耐受性,金黄色葡萄球菌的一种最重要的武器就是分泌α-毒素,这种毒素可以引发人类细胞破坏。近日一项刊登在杂志PNAS上的研究论文中,来自斯坦福大学等处的科学家们通过研究鉴别出了调节细菌毒素毒力的细胞组分,尤其是这种名为PLEKHA7的蛋白质,通过消除这种蛋白的表达,细胞就会从α-毒素的伤害中恢复过来,缺失PLEKHA7蛋白的小鼠会送细菌感染中恢 Staphylococcus aureus is both a short-lived skin-resident and a terrible human pathogen that causes primarily skin and soft tissue infections in the body and severe pneumonia; scientists nowadays try many strategies to fight this pathogen, Bacteria are resistant to antibiotic therapies. One of the most important weapons for Staphylococcus aureus is the secretion of alpha-toxin, which can cause destruction of human cells. In a recent research paper published in the journal PNAS, scientists from Stanford University and elsewhere identified, through research, the cellular components that regulate the virulence of bacterial toxins, especially the protein called PLEKHA7, by eliminating this Protein expression, the cells will recover from the damage of α-toxin, mice lacking PLEKHA7 protein will be sent to the bacterial infection in the recovery