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本文研究患有严重肺血管病的小儿,长期应用氧气治疗的效果.作者于1980年和1981年选择了15例患有严重肺血管病的小儿作为研究对象,年龄为4～18岁.他们患有原发性肺动脉高压,或继发于严重心脏缺损(无法手术或术后肺血管病会持续存在)的肺血管病,不包括肺实质有严重病变的患儿.其中6例为未吸氧组,9例为吸氧组.两组的平均年龄、心导管检查结果及临床病情严重度均无统计学差异.吸氧组在家应用鼻导管、面罩或氧帐,每天吸氧12～15小时.为观察两组患儿的预后差别,临床随访并对症状进行评分,除心导管检查外还应用了心电图、超声心动图以及运动试验等无损伤性方法.每6～12月复查一次,共随访5年.随访结果:吸氧组9例心导管复查资料表明,吸氧时平均肺动脉压力无明显变化,但是肺血流量持续增加,说明肺血管阻力有所降低,虽然各例均未降到8mmHg·1~(-1)·min·m~2(?640dyn·s·cm~(-5)·m~2)
This article investigates the long-term effect of oxygen therapy in pediatric patients with severe pulmonary vascular disease.15 The authors selected 15 children with severe pulmonary vascular disease from 1980 to 1981 as subjects, aged 4-18 years Pulmonary vascular disease secondary to primary pulmonary hypertension or secondary to severe heart failure (persistent inoperable or postoperative pulmonary vascular disease), excluding those with severe disease in the lung parenchyma, of which 6 were non-oxygenated Group, 9 cases of oxygen inhalation group.The average age of the two groups, the results of cardiac catheterization and clinical severity were no significant differences.Oxygen inhalation group at home with nasal cannula, mask or oxygen account, daily oxygen 12 to 15 hours In order to observe the difference of prognosis between the two groups, clinical follow-up and symptom score were performed, besides the catheterization examination, non-invasive methods such as electrocardiogram, echocardiography and exercise test were also applied. Follow up for 5 years.Results: According to the data of 9 cases of cardiac catheterization in oxygen inhalation group, there was no significant change of average pulmonary arterial pressure during oxygen inhalation, but pulmonary blood flow continued to increase, which indicated that the pulmonary vascular resistance was decreased. 8mmHg · 1 ~ (-1) · min · m ~ 2 (? 640dyn · s · cm ~ (-5) · m ~ 2)