Based on the assessment report of destructive housings caused by more than 20 earthquakes occurred in Yunnan Province in 1990～2004, the vulnerability models of 4 types housings of rural residents in Yunnan Province are setup. The scenario earthquake disaster loss model is used to simulate the housing loss if the historical earthquakes that occurred since A.D. 886 in Yunnan Province reoccur in 2002. The analyses show the simulation deviation of the usual earthquakes is less than 30% and the method is of high practicality. Meanwhile, the simulation result of 398 historical earthquakes in Yunnan Province shows that the annual economic loss caused by the earthquakes is about RMB 410 million Yuan that accounts for 0.18% of GDP of Yunnan Province for the year. Because the per capita living area and the price of the housing increases year by year, if the historical destructive earthquake reoccurs today, the loss of Yunnan Province will be greater than in those years.