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采用自制的窒息模型,研究白细胞在窒息后脑损伤中的作用。实验分为对照组和窒息组。在窒息后、复氧24小时检测大脑皮层组织的白细胞数、脂质过氧化物(LPO)含量及病变神经元(变性和/或坏死神经元)数,并在光镜下对脑组织毛细血管充盈不良的程度进行分级。结果:窒息组上述指标与对照组相比,明显升高或加重(P<0.01或0.05),脑组织白细胞数与其LPO含量及病变神经元数之间呈正相关(P<0.05),提示:白细胞通过产生氧自由基,栓塞微血管而加重微循环障碍等途径参与窒息后脑损伤。
A self-made asphyxia model was used to study the role of leukocytes in post-asphyxial brain injury. The experiment was divided into control group and asphyxia group. After asphyxia, the number of white blood cells, the content of LPO and the number of neurons (degenerative and / or necrotic neurons) in the cerebral cortex were detected 24 hours after reoxygenation. The changes of brain tissue capillary The degree of poor filling grading. Results: Compared with the control group, the index of asphyxia group was significantly higher or worse than that of the control group (P <0.01 or 0.05). There was a positive correlation between the number of white blood cells and the content of LPO and the number of neurons in the asphyxia group (P <0. 05), suggesting that leukocytes participate in asphyxial brain injury by generating oxygen free radicals, embolizing capillaries and aggravating microcirculation disorders.