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目的 :观察不同途径给药对卵巢上皮癌化疗疗效的影响。方法 :72例卵巢上皮癌患者均采用 CAP方案化疗 ,其中 A组环磷酰胺、阿霉素 (或吡喃阿霉素 )经静脉滴注 ,顺铂经腹腔灌注 ,B组则全部经静脉滴注。间隔 3～ 4周 ,共 6～ 8个疗程。结果 :A组治疗总有效率 89.47% ( CR65 .79% + PR2 3.69% )。腹水得到有效控制。B组总有效率 67.65 % ( 4 7.0 6% + 2 0 .5 9% )。两组比较有显著差异。两组 3年生存率分别为 47.37%、44.1 2 % ,A组高于 B组 ,但差异不显著。结论 :顺铂腹腔灌注可减轻药物的副反应 ,提高有效率 ,改善患者生存质量 ,但对提高 3年生存率的意义尚不肯定。
Objective: To observe the different routes of administration of ovarian epithelial cancer chemotherapy effect. Methods: 72 cases of patients with epithelial ovarian cancer were treated with CAP chemotherapy, in which group A cyclophosphamide, doxorubicin (or pirarubicin) by intravenous infusion of cisplatin by intraperitoneal perfusion, B group were all via intravenous drip Note. An interval of 3 to 4 weeks, a total of 6 to 8 courses. Results: The total effective rate of group A was 89.47% (CR65 .79% + PR2 3.69%). Ascites is effectively controlled. The total effective rate in group B was 67.65% (4 7.0 6% + 20.59%). There were significant differences between the two groups. The 3-year survival rates of the two groups were 47.37% and 44.1 2%, respectively. The A group was higher than the B group, but the difference was not significant. Conclusion: Intraperitoneal cisplatin can reduce the side effects of drugs, improve the efficiency and improve the quality of life of patients, but the significance of improving 3-year survival rate is still uncertain.